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Endocrine Abstracts

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ea0038p152 | Neoplasia, cancer and late effects | SFEBES2015

Phenotypic heterogeneity associated with proglucagon-expressing tumours is due to differential processing and secretion of proglucagon-derived peptides

Challis Ben , Albrechtsen Nicolai , Bansiya Vishakha , Burling Keith , Barker Peter , Hartmann Bolette , Gribble Fiona , O'Rahilly Stephen , Holst Jens , Simpson Helen

Context: Pancreatic neuroendocrine tumours (NETs) overexpressing glucagon are associated with phenotypic heterogeneity. Objective: To correlate clinical phenotype with detailed analysis of plasma levels of proglucagon-derived peptides (PGDPs) in subjects with proglucagon-expressing tumours using specific immunoassays and gel filtration profiles to elaborate molecular heterogeneity of PGDPs, before and after somatostatin analogues.Case 1: A 57 year old wo...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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